What Is Vitamin B-12?
Vitamin B-12 is an essential water soluble vitamin that is commonly found in a variety of foods such as fish, shellfish, meats, and dairy products. Vitamin B-12 is frequently used in combination with other B vitamins in a vitamin B-complex formulation. It helps maintain healthy nerve cells and red blood cells, and is also needed to make DNA, the genetic material in all cells.
Vitamin B-12 is bound to the protein in food. Hydrochloric acid in the stomach releases B-12 from protein during digestion. Once released, B-12 combines with a substance called intrinsic factor (IF) before it is absorbed into the blood stream. The human body stores several years’ worth of vitamin B-12 so nutritional deficiency of this vitamin is extremely rare.
Vitamin B-12 Deficiency
Without sufficient vitamin B-12, nerves become damaged and folic acid fails to do its blood-building work. Studies have shown that a deficiency in vitamin B-12 can lead to abnormal neurologic and psychiatric symptoms. These symptoms may include: ataxia (shaky movements and unsteady gait), muscle weakness, spasticity, incontinence, hypotension, vision problems, dementia, psychoses, and mood disturbances.
Researchers report that these symptoms may occur when vitamin B-12 levels are just slightly lower than normal and are considerably above the levels normally associated with anemia. The vitamin B-12 deficiency caused by lack of intrinsic factor is known as pernicious anemia.
Why The Risk For Deficiency After Gastric Bypass?
Post-gastric bypass vitamin B-12 deficiency occurs primarily due to poor absorption of dietary B-12. Post sleeve gastrectomy it is due primarily to the lack of sufficient intrinsic factor. Dietary B-12, which is protein bound, must be broken down from food in your stomach.
Intrisinc factor is a protein secreted by the stomach that joins with vitamin B-12 in the stomach and then carries it through the small intestine to be absorbed into your bloodstream. Without intrinsic factor, vitamin B-12 can not be absorbed and leaves the body as a waste.
After gastric bypass, hydrochloric acid and intrinsic factor are absent in the pouch. Food is also bypassing the duodenum, the main site of absorption for vitamin B-12. After sleeve gastrectomy, it is not known how much hydrochloric acid and intrinsic factor is in the pouch. This may lead to vitamin B-12 deficiency. If left untreated for prolonged periods, the resulting nerve damage may be irreversible.
What Are B-Vitamins?
B-vitamins are water-soluble vitamins. The body absorbs these vitamins easily and just as easily excretes them in the urine. Under ordinary circumstances, you need not be concerned about consuming modest excesses. Some of the water-soluble vitamins can remain in the lean tissues for periods of a month or more, but these tissues are actively exchanging materials with the body fluids at all times. At any time, the vitamins may be picked up by the extracellular fluids, carried away by the blood, and excreted in the urine.
Why Is Supplementation Necessary After Bariatric Surgery?
After bariatric surgery, due to intake restriction and the exclusion of some food groups, your diet will not be nutritionally balanced. If the procedure you had done is malabsorptive, you are particularly vulnerable to a vitamin deficiency.
After gastric bypass surgery, you are particularly vulnerable to malabsorption of B vitamins because the duodenum (first section of small intestine) and a variable segment of the upper jejunum (second section of the small intestine) are bypassed - the major sites of absorption. In addition, gastric acid secretion from the small pouch is negligible and absorption of vitamin B-12 and folic acid are severely limited.
During the first few months after surgery, persistent vomiting can occur and can lead to vitamin B-1 (thiamin) deficiency. This deficiency may cause central nervous system damage that is left untreated, may be lethal. Vitamin B-1 supplementation is especially important if stoma stenosis occurs post gastric bypass surgery.
There is also some recent speculation, that vitamin B-1 deficiency is possibly pre-existing (existing prior to surgery). This deficiency may have been present already prior to surgery due to a diet lacking in whole-grains, legumes and leaf-green vegetables and/or due to medications. Vitamin B-1 deficiency in obese populations has been demonstrated.
What Should You Look For In a Supplement?
Keep quantities of B vitamins balanced. One should not take high doses of a single B vitamin without increasing the amount of all others. This is important because B vitamins tend to work together and compete for absorption in the intestines.
In other words, B vitamins are absorbed better when they are taking together and in the same amount. Since the B vitamins found in multiple vitamins are usually present in different amounts, the B vitamins will not be well absorbed. Therefore, an additional B-complex should be taken.
A high-quality vitamin B complex supplement will provide, in one convenient dose, a full range of B vitamins, including biotin, choline, folic acid, inositol, PABA (para-aminobenzoic acid), and the six “numbered” B vitamins – vitamin B-1 (thiamin), B-2 (riboflavin), B-3 (niacin), B-5 (pantothenic acid), and B-12 (cobalamin).
B-complex products are generally available in capsule, chewable and liquid form. When all the B-vitamins are present in the same amount, the complex will be one of the following: B-25, B-50, B-75 or B-100. The number after the “B” is the number of milligrams each B-vitamin is available in. For example, a B-100 complex will contain all B-vitamins in 100 mg each and usually 400 mcg folic acid.
Time-release formulas are not recommended. Time-released vitamins are active over an 8-12 hour period and for the general population, very effective for water-soluble vitamins. However, after gastric bypass, time-release formulas may not dissolve adequately and therefore fail to be absorbed.
Look for supplements that dissolve quickly. Nutrients bound up in hard-coated tablets may never make their way into the blood stream. Loose powder, soft-gel capsules or quickly dissolving tablets are fast-acting forms that permit optimal absorption.
Supplements can be cut up into several small pieces or be chewed before swallowing without loss of potency. The supplement can also be cut in half and taken half in the morning and the other half 8 hours later, in order to get the full benefit of these nutrients over a 24-hour period. The B-complex supplement should be taken early in the day to prevent sleep difficulties later at night.
Optimum Daily Intakes Rather Than RDAs
Numerous studies have demonstrated that most North Americans consume nutritionally poor diets. Marginal nutrient deficiencies exist in a substantial portion of the US population. More than 80% consume less than the Recommended Daily Allowance (RDA). These studies indicate that the chances of consuming a diet meeting the RDA for all nutrients is extremely unlikely for most people. Theoretically it is possible that a healthy individual can get all the nutrition needed from foods, but most do not even come close to meeting all their nutritional needs through diet alone. Optimal health after gastric bypass is possible if nutrition is a major focus of treatment. Because of specialized needs due to decreased absorption of some vitamins and minerals, a well-balanced supplementation program is needed. The importance of your full participation in health decisions can not be stressed enough for non-compliance to be eliminated. Taking the best forms of vitamins and minerals will ensure better assimilation and, in the long run, will be more cost-effective for you.
The RDAs only focus on the prevention of nutritional deficiencies in groups of people. They do not define optimal intakes for an individual, and special nutritional needs such as those produced by gastric surgery are not covered by the RDAs. A tremendous amount of scientific research indicates that the optimal level for many nutrients may be much higher than their current RDAs. Decreased food intake, nutrient-depleted foods, altered absorption and biochemical individuality all point to using Optimum Daily Intake (ODI) rather than RDAs as the basis for vitamin and mineral supplementation after gastric bypass.
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| SUPPLEMENT |
ODIs |
BEST ABSORBED FORM |
Vitamin A |
10000 IU |
Retinol, palm oil carotene,
beta carotene |
Vitamin D |
400 IU |
Cholecalciferol (D3) |
Vitamin C
|
200 mg |
Calcium buffered |
Vitamin E |
60 IU |
d-tocopheryl chelate |
Thiamine (B1)* |
100 mg |
Thiamine-HCl
|
Riboflavin (B2)* |
100 mg |
Riboflavin-5-phosphate, B2
|
Niacin (B3)* |
100 mg |
Inositol hexaniacinate |
Pyridoxine (B6)* |
100 mg |
Pyridoxal-5-phosphate |
Vitamin B12 |
500 - 1000 mcg |
Methylcobalamin
Taken separately |
Folic Acid |
400 μg |
Folinic acid |
Biotin |
100 μg |
Biotin |
Pantothenic Acid (B5)* |
100 mg |
Pantethine |
Choline |
100 mg |
Bitartrate |
Calcium |
1200 - 1500 mg |
Citrate
Taken separately |
Iron |
18 mg |
Gluconate |
Copper |
1 mg |
Chelate |
Iodine |
0.1 mg |
Kelp, iodine caseinate |
Magnesium |
100 mg |
Citrate |
Zinc |
10 mg |
Citrate |
Potassium |
30 mg |
Chelate |
Chromium |
50 μg |
Picolinate |
Selenium |
10 μg |
Yeast, selenomethionine |
Inositol |
100 mg |
Inositol monophosphate |
|
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Other Ingredients:
Artificial colors – added mainly for looks and are not essential for health. Have potential to cause allergic reaction in sensitive individuals.
Artificial flavors – most common in chewable form.
Sugars – common are fructose (fruit sugar), lactose (milk sugar), glucose and sucrose. Important to consider due to dumping syndrome and lactose intolerance.
Artificial sweeteners – sweeteners such as acesulfame-k or aspartame have no health benefit and can be poorly tolerated by some individuals. A better choice is sucralose or small amounts of sugar alcohols (sorbitol, xylitol, maltitol).
Other ingredients- that sometimes show up are hydrogenated or partially hydrogenated fats, starches, and preservatives.
BOTTOM LINE: The shorter the list of “other ingredients”, the better.
Important Aspects of Supplementation
1-Choose high potency supplements.
Taking a high-quality preparation that provides all of the known vitamins and minerals serves as a foundation of a sound nutritional program. Choose preparations by companies that manufacture in small frequent batches. The table below is a composite listing of the ODI dosages and the best absorbable form for each of the vitamins and minerals.
2-Timed-released formulas are not always better.
Time-released vitamins are active over an 8-12 hour period and may be hampered by the timed-release process in gastric bypass. They are not recommended.
3-Keep quantities of B vitamins balanced.
One should not take high doses of a single B vitamin without increasing the amount of all the others. This is important because B vitamins tend to work together, and compete for absorption in the intestines.
4-Aim for maximum absorption.
Look for supplements that dissolve quickly. Nutrients bound up in hard-coated tablets may never make their way into the blood stream. Loose powder, soft-gel capsules or quick dissolving tablets are fast-acting forms that permit optimal absorption. Supplements can be cut up into several small pieces or be chewed before swallowing without loss of potency. In order to get the full benefits of nutrients over a 24-hour period, a supplement may be broken in half. Half should be taken in the morning and the other half 8 hours later. B-complex vitamins should be taken early in the day to prevent sleep difficulties later at night.
Most supplements are best taken with meals to promote better absorption and tolerance. On an empty stomach, water-soluble vitamins can leave as quickly as 2-3 hours after ingestion, while fat-soluble vitamins remain in the body for about 24 hours, with excess amounts being stored in the liver longer.
5-Use chelated minerals.
Minerals are best absorbed from the digestive tract in their chelated form where they are bound to other substances. There are many chelation vehicles on the market with a wide variation in absorption. The ones with the highest absorption efficiencies are malate, ethanolamine, phosphate, ascorbate, citrate, fumarate, peptonate, succinate, lysinate, glycerate, picolinate and acetate. Moderate high efficiency absorption vehicles are amino acid chelate, aspartate, chloride, sulfate, gluconate and phosphate. The lowest absorption efficiency vehicles and the least expensive are carbonate and oxide.
6-Monitor vitamin A and D intakes.
Vitamin A and D have the potential for toxicity. Up to 1,000 IU of vitamin D and 15,000 IU of vitamin A (dietary and supplement sources combined) can be taken safely. Vitamin D is best utilized when taken with vitamin A in natural sources such as fish oils.
7-Check mineral ratios in supplements.
Zinc and copper antagonize each other. To maintain good health, keep the ratio between zinc and copper at 10:1 or 15:1. Calcium and magnesium should be present in supplements in a ration of 2:1 ratio. Magnesium taken in a 1:1 ratio to calcium could cause diarrhea in susceptible individuals. Vitamin D should be taken with calcium supplements to promote absorption.
8-Monitor vitamin-mineral combinations.
Iron fumarate and sulfate destroy vitamin E. It is not affected by iron chelated to gluconate, fumarate or citrate. Vitamin C taken concurrently with vitamin B-12 destroys its activity. Zinc is required to utilize vitamins A and B. Bioflavonoids (vitamin P) are essential for the proper absorption of vitamin C. Selenium improves vitamin E activity considerably. High coffee, soft drink and sugar intakes deplete B vitamins, zinc and calcium.
9-Synthetic versus natural preparations.
Most vitamins are synthetic even if their labels say “natural”. The cost of “all natural” vitamins would be prohibitive. The body recognizes and uses molecules of most synthetic vitamins. One notable exception is vitamin E. Synthetic vitamin E, the dl form, has very little vitamin E activity. Use the d form only. Synthetic fat-soluble vitamins are difficult for the liver to utilize properly. Use natural North Atlantic fish oil sources free from heavy metal residues to provide vitamins A and D to treat impaired health, especially in sun-starved climates.
10-Do not adjust supplement dosages without supervision.
Some practicioners advocate periodically discontinuing or at least reducing the dosages of vitamin and mineral supplements for 1-2 days per week during leisure time, and for one or more weeks every 3-4 months, especially when on vacation or in a quieter, cleaner, less stressful environment. This is not possible with the high nutrient requirements demanded of the gastric bypass. For example, studies have shown vitamin B-12 levels to decline rapidly over a 3-month period when supplementation was discontinued. Keep in mind that modifying your vitamin / mineral supplementation without the super vision of your dietitian or physician, may precipitate a deficiency.
11-Oral versus injectable preparations.
Oral vitamin therapy is more reliable, less burdensome and less costly than the injectable form, but does require compliance on your part. However, if the oral form of a vitamin or mineral is not working well, you may require the injectable form. For example, you may require injectable iron or vitamin B-12 due to intolerance or diminished intestinal ab sorption. |
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